Context-specific effects of NOX4 inactivation in acute myeloid leukemia (AML).

ABSTRACT:

Purpose

Oxidative stress has been linked to initiation and progression of cancer and recent studies have indicated a potential translational role regarding modulation of ROS in various cancers, including acute myeloid leukemia (AML). Detailed understanding of the complex machinery regulating ROS including its producer elements in cancer is required to define potential translational therapeutic use. Based on previous studies in acute myeloid leukemia (AML) models, we considered NADPH oxidase (NOX) family members, specifically NOX4 as a potential target in AML.

Methods

Pharmacologic inhibition and genetic inactivation of NOX4 in murine and human models of AML were used to understand its functional role. For genetic inactivation, CRISPR-Cas9 technology was used in human AML cel

SUBMITTER: Demircan MB 

PROVIDER: S-EPMC9293823 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature