The effects of nalmefene on the impulsive and reflective system in alcohol use disorder: A resting-state fMRI study.

ABSTRACT:

Rationale

Central aspects of alcohol use disorder (AUD) are the irresistible desire for alcohol and impaired control over its intake. According to the triadic neurocognitive model of addiction, this arises from aberrant functioning of different neural and cognitive systems: an impulsive system, a reflective system, and the abnormal dynamics between both systems based on an insular-dependent system.

Objectives

In this study, we examined the effects of a single dose of nalmefene on resting-state functional connectivity (rsFC) patterns within and between these addiction-related neural systems in AUD.

Methods

Non-treatment seeking participants with AUD (N = 17; 19-66 years, 6 female) took part in a randomized, placebo-controlled, double-blind, crossover study and received

SUBMITTER: Grundinger N 

PROVIDER: S-EPMC9293828 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature