Dataset Information

Risk of mortality from suicide in patients with Huntington's disease is increased compared to the general population in England.

ABSTRACT:

Objective

To examine the relative risk of suicide mortality in patients with Huntington's disease (HD).

Methods

A case-control study design was used. We used linked electronic records from primary care, secondary care and Office for National Statistics from England from 2001 through 2019. Controls were matched to cases by general practice and suicide date. Odds ratios (ORs) were adjusted for gender and age at suicide/index date.

Results

Data were available for 594,674 individuals. Patients with HD who died from suicide were significantly younger at time of death than patients with HD who died from causes other than suicide (p < 0.001). The adjusted OR for HD was 9.2 (95% confidence intervals, CI 4.9-17.4) compared to those without HD. The increase in risk was higher amongst the younger age group who were ≤ 45.8 years at suicide/index date (OR 54.5, 95% CI 10.8-276.1).

Conclusion

The markedly elevated suicide risk in patients with HD suggests that implementation of suicide risk assessment may improve survival in individuals with these diseases, especially in younger patients.

SUBMITTER: Alothman D

PROVIDER: S-EPMC9293836 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Risk of mortality from suicide in patients with Huntington's disease is increased compared to the general population in England.

Alothman Danah D Marshall Charles R CR Tyrrell Edward E Lewis Sarah S Card Timothy T Fogarty Andrew A

Journal of neurology 20220327 8

<h4>Objective</h4>To examine the relative risk of suicide mortality in patients with Huntington's disease (HD).<h4>Methods</h4>A case-control study design was used. We used linked electronic records from primary care, secondary care and Office for National Statistics from England from 2001 through 2019. Controls were matched to cases by general practice and suicide date. Odds ratios (ORs) were adjusted for gender and age at suicide/index date.<h4>Results</h4>Data were available for 594,674 indiv ...[more]

PMID: 35344078

Similar Datasets

Project description:BackgroundAlthough clinical trials involving psychedelic-assisted psychotherapy have not observed short-term increases in the risk of death, limited data exist on mortality associated with hallucinogen use outside of controlled trial settings. We sought to determine whether people with an emergency department visit or hospital admission involving hallucinogen use were at increased risk of all-cause death compared with the general population and with people with acute care presentations involving other substances.MethodsWe conducted a retrospective cohort study using linked health administrative data on all people aged 15 years and older living in Ontario, Canada, from 2006 to 2022. We compared overall and cause-specific mortality between members of the general population and people with incident acute care (an emergency department visit or hospital admission) involving hallucinogens and other substances.ResultsWe included 11 415 713 people; 7953 (0.07%) had incident acute care involving hallucinogens. In a matched analysis with 77 101 people with a median follow-up of 7 (interquartile range 3-11) years, acute care involving hallucinogens was associated with a 2.6-fold (hazard ratio [HR] 2.57, 95% confidence interval [CI] 2.09-3.15) increased all-cause mortality within 5 years (n = 482, absolute risk 6.1%) relative to the general population (n = 460, absolute risk 0.6%). Analyses excluding people with comorbid mental or substance use disorders showed similar elevations in mortality risk for acute care involving hallucinogens relative to the general population (HR 3.25, 95% CI 2.27-4.63). People with acute care involving hallucinogens were at a significantly elevated risk of death by unintentional drug poisoning (HR 2.03, 95% CI 1.02-4.05), suicide (HR 5.23, 95% CI 1.38-19.74), respiratory disease (HR 2.46, 95% CI 1.18-5.11), and cancer (HR 2.88, 95% CI 1.61-5.14) relative to the general population.InterpretationRequiring hospital-based care for hallucinogen use was associated with increases in risk of death relative to the general population, particularly from suicide. These findings should be considered in clinical and policy decision-making, given the increasing use of hallucinogens and associated problematic use.

Dataset Information

Risk of mortality from suicide in patients with Huntington's disease is increased compared to the general population in England.

Objective

Methods

Results

Conclusion

Publications

Risk of mortality from suicide in patients with Huntington's disease is increased compared to the general population in England.

Similar Datasets

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