Alterations of circulating lymphocyte subsets in patients with colorectal carcinoma.

ABSTRACT:

Introduction

Cellular immune response to cancer is known to be of great importance for tumor control. Moreover, solid tumors influence circulating lymphocytes, which has been shown for several types of cancer. In our prospective study we elucidate changes in lymphocyte subsets in patients with colorectal carcinoma compared to healthy volunteers.

Methods

Flow cytometry was performed at diagnosis of colon carcinoma to analyze B cells, T cells and NK cells including various subtypes of each group. Univariate and multivariate analyses including age, gender, tumor stage, sidedness and microsatellite instability status (MSI) were performed.

Results

Forty-seven patients and 50 healthy volunteers were included. Median age was 65 years in patients and 43 years in the control g

SUBMITTER: Waidhauser J 

PROVIDER: S-EPMC9293872 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature