COVID-19 symptom severity predicts neutralizing antibody activity in a community-based serological study.

ABSTRACT: Serological testing for SARS-CoV-2 IgG antibodies is used to assess their presence in blood samples from exposed individuals and provides a measure of the magnitude of immune response to infection. The measurement of neutralizing antibodies (NAbs) in particular provides information about the severity of prior infection and level of protective immunity against re-infection. Much of the work investigating the association between prior infection severity and NAb levels has been conducted among clinical populations, and less is known about this relationship in the general population. Accordingly, we utilize data from a large (n = 790) community-based cohort of unvaccinated, seropositive participants. We analyzed the association between NAb response, measured via surrogate virus neutralization

SUBMITTER: Sancilio A 

PROVIDER: S-EPMC9293881 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature