Allergic sensitization trajectories to age 8 years in the Singapore GUSTO cohort☆

ABSTRACT:

Background

Allergic sensitization is linked to allergy development, with early sensitization often associated with worse outcomes. We aimed to identify if distinct allergic sensitization trajectories existed within a diverse and multi-ethnic Asian cohort.

Methods

We administered modified ISAAC questionnaires in the first 8 years and conducted skin prick testing at ages 18 months, 3, 5 and 8 years in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. We used latent class analysis to derive allergic sensitization trajectories, and adjusted odds ratios (AOR) to evaluate predictive risk factors and associations with allergic comorbidities.

Results

Among 997 children, three trajectories were identified: early food and mite sensitization (16.2%), late

SUBMITTER: Lau H 

PROVIDER: S-EPMC9293943 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature