The incidence, baseline predictors, and outcomes of dementia in an incident cohort of Parkinson's disease and controls.

ABSTRACT:

Background

There are few long-term data on the incidence, baseline predictors, and outcomes of dementia in Parkinson's disease (PD) from prospective community-based incident cohorts.

Methods

The PINE study prospectively identified all incident PD patients in Aberdeen along with age-sex-matched, community-based controls who consented to standardized annual life-long follow-up. Each year, a clinical expert reviewed the diagnosis of PD and the presence of dementia according to DSM-IV-based criteria. Age-sex stratified incidence rates for dementia in PD and controls were calculated and compared with hazard ratios (HR) adjusted for age, sex, education, and socioeconomic status. Cox proportional-hazard modelling was used to assess baseline predictors for PD dementia and the influe

SUBMITTER: Counsell C 

PROVIDER: S-EPMC9294013 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature