Anti-complement Agents for Autoimmune Neurological Disease.

ABSTRACT: In recent years, there has been increasing recognition of the diversity of autoimmune neurological diseases affecting all levels of the nervous system. A growing understanding of disease pathogenesis has enabled us to better target specific elements of the immune system responsible for the cell dysfunction and cell destruction seen in these diseases. This is no better demonstrated than in the development of complement directed therapies for the treatment of complement mediated autoimmune neurological conditions. Herein, we describe the basic elements of the complement cascade, provide an overview of select autoimmune neurological diseases whose pathogenesis is mediated by complement, the effector system of autoantigen bound autoantibodies, and discuss the complement directed therapies tria

SUBMITTER: McCombe JA 

PROVIDER: S-EPMC9294087 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature