Fast versus slow infusion of 20% albumin: a randomized controlled cross-over trial in volunteers.

ABSTRACT:

Background

We investigated whether plasma volume (PV) expansion of 20% albumin is larger when the fluid is administered rapidly compared with a slow infusion.

Methods

In this open-labeled randomized interventional controlled trial, 12 volunteers (mean age, 28 years) received 3 mL/kg of 20% albumin (approximately 225 mL) over 30 min (fast) and 120 min (slow) in a cross-over fashion. Blood hemoglobin and plasma albumin were measured on 15 occasions during 6 h to estimate the PV expansion and the capillary leakage of albumin and fluid.

Results

The largest PV expansion was 16.1% ± 6.5% (mean ± SD) for fast infusion and 12.8% ± 4.0% for slow infusion (p = 0.52). The median area under the curve for the PV expansion was 69% larger for the fast infusion during the first 2 h (

SUBMITTER: Zdolsek M 

PROVIDER: S-EPMC9294107 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature