Evolution of Anti-B Cell Therapeutics in Autoimmune Neurological Diseases.

ABSTRACT: B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurological disorders, acting as antigen-presenting cells facilitating antibody production but also as sensors, coordinators, and regulators of the immune response. In particular, B cells can regulate the T cell activation process through their participation in antigen presentation, production of proinflammatory cytokines (bystander activation or suppression), and contribution to ectopic lymphoid aggregates. Such an important interplay between B and T cells makes therapeutic depletion of B cells an attractive treatment strategy. The last decade, anti-B cell therapies using monoclonal antibodies against B cell surface molecules have evolved into a rational approach for successfully treating autoimmune neuro

SUBMITTER: Stathopoulos P 

PROVIDER: S-EPMC9294112 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature