Antibody Therapies in Autoimmune Inflammatory Myopathies: Promising Treatment Options.

ABSTRACT: Inflammatory myopathies, including polymyositis (PM), dermatomyositis (DM), inclusion body myositis (IBM), necrotizing myopathy (NM), antisynthetase syndrome (ASS) and overlap myositis (OM), in short myositis, are rare diseases. All forms of myositis have progressive muscle weakness in common, with each subtype characterized by different autoantibody profiles, histological findings and extramuscular manifestations. Due to better understanding of the pathogenesis of the muscle inflammation in myositis, new molecular pathways for targeted therapy have been discovered. Current therapies aim at different components of the innate or the adaptive immune response. Additionally, non-inflammatory mechanisms in myositis have come into focus as possible treatment targets. The use of therapeutical ant

SUBMITTER: Zeng R 

PROVIDER: S-EPMC9294121 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature