Long-Term Responders After Autologous Stem Cell Transplantation in Multiple Myeloma.

ABSTRACT:

Introduction

Multiple myeloma (MM) is considered an incurable hematological neoplasm. For transplant-eligible patients, initial treatment includes an induction phase followed by an autologous stem cell transplantation (ASCT). Despite the introduction of several drugs in the past years, relapses still occur. Nevertheless, some patients achieve sustained responses after successful induction treatment and ASCT.

Methods

We retrospectively evaluated all patients diagnosed with MM in our institution who underwent induction treatment and ASCT between 1990 and 2015. The subset of patients who achieved a sustained response (any degree) for 5 or more years after ASCT without further treatment or signs of progression were distinguished as "long-term responders" (LTRs). In the non-LTR g

SUBMITTER: Oliver-Caldes A 

PROVIDER: S-EPMC9294166 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature