M6A Topological Transition Coupled to Developmental Regulation of Gene Expression During Mammalian Tissue Development.

ABSTRACT: N6-methyladenosine (m6A) is the most prevalent internal modification and reversible epitranscriptomic mark in messenger RNAs (mRNAs) and plays essential roles in a variety of biological processes. However, the dynamic distribution patterns of m6A and their significance during mammalian tissue development are poorly understood. Here, we found that based on m6A distribution patterns, protein-coding genes were classified into five groups with significantly distinct biological features and functions. Strikingly, comparison of the m6A methylomes of multiple mammalian tissues between fetal and adult stages revealed dynamic m6A topological transition during mammalian tissue development, and identified large numbers of genes with significant m6A loss in 5'UTRs or m6A gain around stop codons. The g

SUBMITTER: Li S 

PROVIDER: S-EPMC9294180 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature