Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule.

ABSTRACT: Protein seldom performs biological activities in isolation. Understanding the protein-protein interactions' physical rewiring in response to pathological conditions or pathogen infection can help advance our comprehension of disease etiology, progression, and pathogenesis, which allow us to explore the alternate route to control the regulation of key target interactions, timely and effectively. Nonalcoholic steatohepatitis (NASH) is now a global public health problem exacerbated due to the lack of appropriate treatments. The most advanced anti-NASH lead compound (selonsertib) is withdrawn, though it is able to inhibit its target Apoptosis signal-regulating kinase 1 (ASK1) completely, indicating the necessity to explore alternate routes rather than complete inhibition. Understanding the int

SUBMITTER: Agrahari AK 

PROVIDER: S-EPMC9294202 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature