Differential Microbial Signature Associated With Benign Prostatic Hyperplasia and Prostate Cancer.

ABSTRACT: Apart from other risk factors, chronic inflammation is also associated with the onset of Prostate Cancer (PCa), wherein pathogen infection and tissue microbiome dysbiosis are known to play a major role in both inflammatory response and cancer development. However, except for a few studies, the link between microbes and PCa remained poorly understood. To explore the potential microbiome signature associated with PCa in Indian patients, we investigated differential compositions of commensal bacteria among patients with benign prostatic hyperplasia (BPH) and PCa using 16S rRNA amplicon sequencing followed by qPCR analyses using two distinct primer sets. Using two independent cohorts, we show that Prevotella copri, Cupriavidus campinensis, and Propionibacterium acnes repre

SUBMITTER: Sarkar P 

PROVIDER: S-EPMC9294280 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature