Aberrant dynamic structure-function relationship of rich-club organization in treatment-naive newly diagnosed juvenile myoclonic epilepsy.

ABSTRACT: Neuroimaging studies have shown that juvenile myoclonic epilepsy (JME) is characterized by impaired brain networks. However, few studies have investigated the potential disruptions in rich-club organization-a core feature of the brain networks. Moreover, it is unclear how structure-function relationships dynamically change over time in JME. Here, we quantify the anatomical rich-club organization and dynamic structural and functional connectivity (SC-FC) coupling in 47 treatment-naïve newly diagnosed patients with JME and 40 matched healthy controls. Dynamic functional network efficiency and its association with SC-FC coupling were also calculated to examine the supporting of structure-function relationship to brain information transfer. The results showed that the anatomical rich-club orga

SUBMITTER: Liu G 

PROVIDER: S-EPMC9294302 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature