Causal Relationships Between Total Physical Activity and Ankylosing Spondylitis: A Mendelian Randomization Study.

ABSTRACT:

Background

Currently, there is little literature about the association between physical activity (PA) and the risk of ankylosing spondylitis (AS). The present study aimed to understand the causal relationships between PA and AS.

Methods

We performed two-sample Mendelian randomization (MR) using publicly released genome-wide association studies summary statistics to estimate the causal associations of PA with AS risk. The inverse variance weighted (IVW) method was utilized as primary MR analysis. Furthermore, sensitivity, pleiotropy, and heterogeneity analyses were then conducted to assess the robustness of the findings of the present study.

Results

Results of the IVW analysis suggested a protective relationship between accelerometer-based PA and AS (average accelerati

SUBMITTER: Hu S 

PROVIDER: S-EPMC9294357 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature