A Novel Systemic Inflammation Prognostic Score to Stratify Survival in Elderly Patients With Cancer.

ABSTRACT:

Background

Elderly patients with cancer face the challenge of systemic inflammation, which can lead to a poor prognosis. Existing inflammatory indices cannot fully reflect the immune-inflammatory status of patients. This study aimed to develop a new scoring system to predict the survival of elderly patients with cancer using inflammatory indices, namely, the systemic inflammation prognostic score (SIPS).

Materials and methods

This prospective multicenter study included a total of 1,767 patients with cancer, with a mean age of 70.97 ± 5.49 years, of whom 1,170 (66.2%) were men. We performed the least absolute shrinkage and selection operator (LASSO) regression to screen inflammatory indicators to include in constructing SIPS. Prognostic analysis of SIPS was performed using un

SUBMITTER: Ruan GT 

PROVIDER: S-EPMC9294408 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature