Accurate identification of bacteriophages from metagenomic data using Transformer.

ABSTRACT:

Motivation

Bacteriophages are viruses infecting bacteria. Being key players in microbial communities, they can regulate the composition/function of microbiome by infecting their bacterial hosts and mediating gene transfer. Recently, metagenomic sequencing, which can sequence all genetic materials from various microbiome, has become a popular means for new phage discovery. However, accurate and comprehensive detection of phages from the metagenomic data remains difficult. High diversity/abundance, and limited reference genomes pose major challenges for recruiting phage fragments from metagenomic data. Existing alignment-based or learning-based models have either low recall or precision on metagenomic data.

Results

In this work, we adopt the state-of-the-art language model, Tr

SUBMITTER: Shang J 

PROVIDER: S-EPMC9294416 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature