Quantitative estimation of intracellular oxidative stress in human tissues.

ABSTRACT: Oxidative stress is known to be involved in and possibly a key driver of the development of numerous chronic diseases, including cancer. It is highly desired to have a capability to reliably estimate the level of intracellular oxidative stress as it can help to identify functional changes and disease phenotypes associated with such a stress, but the problem proves to be very challenging. We present a novel computational model for quantitatively estimating the level of oxidative stress in tissues and cells based on their transcriptomic data. The model consists of (i) three sets of marker genes found to be associated with the production of oxidizing molecules, the activated antioxidation programs and the intracellular stress attributed to oxidation, respectively; (ii) three polynomial functi

SUBMITTER: Bai J 

PROVIDER: S-EPMC9294418 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature