Circulating cardiac biomarkers improve risk stratification for incident cardiovascular disease in community dwelling populations.

ABSTRACT:

Background

Plasma cardiac markers may assist in prediction of incident cardiovascular disease.

Methods

The incremental value of cardiac Troponins (T and I) and NT-proBNP added to risk factors in the PREDICT score for incident cardiovascular disease (CVD) in primary care, was assessed in 4102 asymptomatic participants in a randomised controlled trial of Vitamin D (ViDA). Findings were corroborated in 2528 participants in a separate community-based observational registry of CVD-free volunteers (HVOLS).

Findings

Hazard ratios for first cardiovascular events adjusted for PREDICT risk factors, comparing fifth to first quintiles of marker plasma concentrations, were 2.57 (95% CI 1.47-4.49); 3.01 (1.66-5.48) and 3.38 (2.04-5.60) for hs-cTnI, hs-cTnT and NT-proBNP respectivel

SUBMITTER: Wu Z 

PROVIDER: S-EPMC9294489 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature