Stochasticity of poly(2-oxazoline) oligomer hydrolysis determined by tandem mass spectrometry.

ABSTRACT: Understanding modification of synthetic polymer structures is necessary for their accurate synthesis and potential applications. In this contribution, a series of partially hydrolyzed poly(2-oxazoline) species were produced forming poly[(2-polyoxazoline)-co-(ethylenimine)] (P(EtOx-co-EI)) copolymers; EI being the hydrolyzed product of Ox. Bulk mass spectrometry (MS) measurements accurately measured the EI content. Tandem mass spectrometry analysis of the EI content in the copolymer samples determined the distribution of each monomer within the copolymer and corresponded to a theoretically modelled random distribution. The EI distribution across the polymers was shown to be effected by the choice of terminus, with a permanent hydrolysis event observed at an OH terminus. A neig

SUBMITTER: Morgan TE 

PROVIDER: S-EPMC9294869 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature