Burden of SARS-CoV-2 infection in healthcare workers during second wave in England and impact of vaccines: prospective multicentre cohort study (SIREN) and mathematical model.

ABSTRACT:

Objective

To describe the incidence of, risk factors for, and impact of vaccines on primary SARS-CoV-2 infection during the second wave of the covid-19 pandemic in susceptible hospital healthcare workers in England.

Design

Multicentre prospective cohort study.

Setting

National Health Service secondary care health organisations (trusts) in England between 1 September 2020 and 30 April 2021.

Participants

Clinical, support, and administrative staff enrolled in the SARS-CoV-2 Immunity and Reinfection Evaluation (SIREN) study with no evidence of previous infection. Vaccination status was obtained from national covid-19 vaccination registries and self-reported.

Main outcome measure

SARS-CoV-2 infection confirmed by polymerase chain reaction. Mixed effects logi

SUBMITTER: Pople D 

PROVIDER: S-EPMC9295077 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature