High-flow nasal cannula oxygen therapy versus noninvasive ventilation for patients with blunt chest trauma: protocol for a randomized controlled trial.

ABSTRACT:

Background

High-flow nasal cannula oxygen therapy (HFNC) is recommended by some scholars as an optimized respiratory support method for blunt chest trauma (BCT) patients. The basis of this recommendation is limited, however, and the efficacy of HFNC or noninvasive ventilation (NIV) in BCT patients has not yet been rigorously explored. This study aims to determine if HFNC is non-inferior to NIV in reducing treatment failure in moderate to severe BCT patients with acute respiratory failure.

Methods

This will be a prospective, open-label, multicenter, non-inferiority, randomized controlled trial. Moderate to severe BCT patients with acute respiratory failure (100mmHg < PaO₂/FiO₂ ≦ 200mmHg) who do not need immediate intubation will be randomized to HFNC or

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC9295083 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature