Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC9295135 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Wang Yuangao Y Wang Meng M Djekidel Mohamed Nadhir MN Chen Huan H Liu Di D Alt Frederick W FW Zhang Yi Y
Nature 20211020 7884
Extrachromosomal circular DNA elements (eccDNAs) have been described in the literature for several decades, and are known for their broad existence across different species<sup>1,2</sup>. However, their biogenesis and functions are largely unknown. By developing a new circular DNA enrichment method, here we purified and sequenced full-length eccDNAs with Nanopore sequencing. We found that eccDNAs map across the entire genome in a close to random manner, suggesting a biogenesis mechanism of rando ...[more]