Facile production of quercetin nanoparticles using 3D printed centrifugal flow reactors.

ABSTRACT: Drug nanocrystals are a delivery system comprised of an active pharmaceutical ingredient, with small amounts of a surface stabilizer. Despite offering simplicity in formulation, their manufacture can be a challenging endeavour; this is especially true when the production is performed using microfluidic devices. Although precipitation within microchannels can lead to issues such as clogging, microfluidics is an appealing manufacturing method as it provides fine control over mixing conditions. This allows production of nanoparticles with a narrower size distribution and greater reproducibility compared to batch methods. To generate microfluidic devices cost effectively, replica moulding techniques are considered the manufacturing standard. Due to its simplicity and relatively low cost, 3D pr

SUBMITTER: De Grandi D 

PROVIDER: S-EPMC9295137 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature