Clinical and genetic spectrum of primary ciliary dyskinesia in Chinese patients: a systematic review.

ABSTRACT:

Background

Primary ciliary dyskinesia (PCD) represents a highly heterogenous disorder with extensive clinical and genetic patterns among populations of different geographic location and ethnic origin. However, data about Chinese patients are limited. We aimed to summarize the clinical and genetic spectrum of Chinese PCD patients based on all available literatures.

Methods

We searched Embase, Pubmed, Web of Science and Chinese databases including CNKI, SinoMed and Wanfang from 1981 to 2021, to identify articles reporting patients with PCD in China, which had included information about transmission electron microscopy and/or genetic testing.

Results

A total of 244 Chinese PCD patients in 52 articles were included. Of these patients, the mean age was 13.1 years, and 55 p

SUBMITTER: Peng B 

PROVIDER: S-EPMC9295413 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature