Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle.

ABSTRACT:

Background

Mitochondria have an essential role in regulating metabolism and integrate environmental and physiological signals to affect processes such as cellular bioenergetics and response to stress. In the metabolically active skeletal muscle, mitochondrial biogenesis is one important component contributing to a broad set of mitochondrial adaptations occurring in response to signals, which converge on the biogenesis transcriptional regulator peroxisome proliferator-activated receptor coactivator 1-alpha (PGC-1α), and is central to the beneficial effects of exercise in skeletal muscle. We investigated the role of long non-coding RNA (lncRNA) taurine-upregulated gene 1 (TUG1), which interacts with PGC-1α in regulating transcriptional responses to exercise in skeletal muscle.

Res

SUBMITTER: Trewin AJ 

PROVIDER: S-EPMC9295458 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature