Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women.

ABSTRACT:

Background

Cardiovascular disease (CVD) remains the leading cause of death among postmenopausal women but standard primary prevention strategies in women are not as effective as in men. By comparison, the Early versus Late Intervention Trial with Estradiol (ELITE) study demonstrated that hormone therapy (HT) was associated with significant reduction in atherosclerosis progression in women who were within six years of menopause compared to those who were 10 or more years from menopause. These findings are consistent with other studies showing significant reductions in all-cause mortality and CVD with HT, particularly when initiated in women younger than 60 years of age or within 10 years since menopause. To explore the biological mechanisms underlying the age-related atheroprotectiv

SUBMITTER: Hilser JR 

PROVIDER: S-EPMC9295504 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature