Multi-dimensional characterization of prediabetes in the Project Baseline Health Study.

ABSTRACT:

Background

We examined multi-dimensional clinical and laboratory data in participants with normoglycemia, prediabetes, and diabetes to identify characteristics of prediabetes and predictors of progression from prediabetes to diabetes or reversion to no diabetes.

Methods

The Project Baseline Health Study (PBHS) is a multi-site prospective cohort study of 2502 adults that conducted deep clinical phenotyping through imaging, laboratory tests, clinical assessments, medical history, personal devices, and surveys. Participants were classified by diabetes status (diabetes [DM], prediabetes [preDM], or no diabetes [noDM]) at each visit based on glucose, HbA1c, medications, and self-report. Principal component analysis (PCA) was performed to create factors that were compared across g

SUBMITTER: Chatterjee R 

PROVIDER: S-EPMC9295520 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature