Effects of prophylactic antibiotic administration and antibiotic timing on culture results and clinical outcomes of paediatric musculoskeletal infection: a protocol for a randomised controlled clinical trial.

ABSTRACT:

Introduction

Musculoskeletal infection (MSI) is a common cause of morbidity among the paediatric population. Some clinicians recommend withholding prophylactic antibiotics until culture collection with an aim to improve the culture sensitivity. However, a recent retrospective study reported that prophylactic antibiotic administration did not affect culture sensitivities in either disseminated or local MSI in paediatric population, which is surprising. The aim of the present study is to investigate the effects of prophylactic antibiotic administration and the timing of antibiotic administration on culture sensitivity and clinical outcomes of paediatric MSI.

Methods and analysis

A randomised controlled clinical trial will be carried out. Individuals aged 0-18 years with a diag

SUBMITTER: Xia Y 

PROVIDER: S-EPMC9295648 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature