Anti-glomerular Basement Membrane Glomerulonephritis: A Study in Real Life.

ABSTRACT:

Introduction

Anti-glomerular basement membrane (anti-GBM) disease is a severe entity with few therapeutic options including plasma exchange and immunosuppressive agents. The aim of this study was to analyze the clinical and pathological features that predict the evolution of end-stage kidney disease (ESKD) and the kidney survival in a cohort of patients with anti-GBM disease with renal involvement in real life.

Methods

A retrospective multicentre observational study including 72 patients from 18 nephrology departments with biopsy-proven anti-GBM disease from 1999 to 2019 was performed. Progression to ESKD in relation to clinical and histological variables was evaluated.

Results

Creatinine at admission was 8.6 (± 4) mg/dL and 61 patients (84.7%) required dialysis. Sixt

SUBMITTER: Sanchez-Agesta M 

PROVIDER: S-EPMC9295717 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature