Basolateral amygdala activation enhances object recognition memory by inhibiting anterior insular cortex activity.

ABSTRACT: Noradrenergic activation of the basolateral amygdala (BLA) by emotional arousal enhances different forms of recognition memory via functional interactions with the insular cortex (IC). Human neuroimaging studies have revealed that the anterior IC (aIC), as part of the salience network, is dynamically regulated during arousing situations. Emotional stimulation first rapidly increases aIC activity but suppresses it in a delayed fashion. Here, we investigated in male Sprague-Dawley rats whether the BLA influence on recognition memory is associated with an increase or suppression of aIC activity during the postlearning consolidation period. We first employed anterograde and retrograde viral tracing and found that the BLA sends dense monosynaptic projections to the aIC. Memory-enhancing norepin

SUBMITTER: Chen YF 

PROVIDER: S-EPMC9295787 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature