Ontology highlight
ABSTRACT:
SUBMITTER: Rosas-Salvans M
PROVIDER: S-EPMC9295892 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Rosas-Salvans Miquel M Sutanto Renaldo R Suresh Pooja P Dumont Sophie S
Current biology : CB 20220516 12
The kinetochore links chromosomes to spindle microtubules to drive chromosome segregation at cell division. While we know nearly all mammalian kinetochore proteins, how these give rise to the strong yet dynamic microtubule attachments required for function remains poorly understood. Here, we focus on the Astrin-SKAP complex, which localizes to bioriented kinetochores and is essential for chromosome segregation but whose mechanical role is unclear. Live imaging reveals that SKAP depletion dampens ...[more]