Ontology highlight
ABSTRACT:
SUBMITTER: Taylor T
PROVIDER: S-EPMC9296009 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Taylor Tiegh T Sikorska Natalia N Shchuka Virlana M VM Chahar Sanjay S Ji Chenfan C Macpherson Neil N NN Moorthy Sakthi D SD de Kort Marit A C MAC Mullany Shanelle S Khader Nawrah N Gillespie Zoe E ZE Langroudi Lida L Tobias Ian C IC Lenstra Tineke L TL Mitchell Jennifer A JA Sexton Tom T
Genes & development 20220616 11-12
How distal regulatory elements control gene transcription and chromatin topology is not clearly defined, yet these processes are closely linked in lineage specification during development. Through allele-specific genome editing and chromatin interaction analyses of the <i>Sox2</i> locus in mouse embryonic stem cells, we found a striking disconnection between transcriptional control and chromatin architecture. We traced nearly all <i>Sox2</i> transcriptional activation to a small number of key tr ...[more]