Characterization of the Genomic and Immunologic Diversity of Malignant Brain Tumors through Multisector Analysis.

ABSTRACT: Despite some success in secondary brain metastases, targeted or immune-based therapies have shown limited efficacy against primary brain malignancies such as glioblastoma (GBM). Although the intratumoral heterogeneity of GBM is implicated in treatment resistance, it remains unclear whether this diversity is observed within brain metastases and to what extent cancer cell-intrinsic heterogeneity sculpts the local immune microenvironment. Here, we profiled the immunogenomic state of 93 spatially distinct regions from 30 malignant brain tumors through whole-exome, RNA, and T-cell receptor sequencing. Our analyses identified differences between primary and secondary malignancies, with gliomas displaying more spatial heterogeneity at the genomic and neoantigen levels. In addition, this spatial d

SUBMITTER: Schaettler MO 

PROVIDER: S-EPMC9296070 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature