Macrophage-inducible C-type lectin activates B cells to promote T cell reconstitution in heart allograft recipients.

ABSTRACT: Diminishing homeostatic proliferation of memory T cells is essential for improving the efficacy of lymphoablation in transplant recipients. Our previous studies in a mouse heart transplantation model established that B lymphocytes secreting proinflammatory cytokines are critical for T cell recovery after lymphoablation. The goal of the current study was to identify mediators of B cell activation following lymphoablation in allograft recipients. Transcriptome analysis revealed that macrophage-inducible C-type lectin (Mincle, Clec4e) expression is up-regulated in B cells from heart allograft recipients treated with murine anti-thymocyte globulin (mATG). Recipient Mincle deficiency diminishes B cell production of pro-inflammatory cytokines and impairs T lymphocyte reconstitution. Mixed bone m

SUBMITTER: Hasgur S 

PROVIDER: S-EPMC9296143 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature