The Relationship between VEGFC Gene Polymorphisms and Autoimmune Thyroiditis.

ABSTRACT:

Background

Autoimmune thyroid diseases (AITDs), representative autoimmune diseases, mainly consist of Graves' disease (GD) and Hashimoto's thyroiditis (HT). In this passage, we investigated the association between vascular endothelial growth factor C (VEGFC) gene polymorphisms and AITDs.

Methods

A total of 1084 patients with AITDs and 794 healthy controls were tested for VEGFC gene genotypes in four single nucleotide polymorphisms (SNPs) by high-throughput sequencing, and the correlation between VEGFC gene polymorphisms and AITDs was statistically analyzed.

Results

The genotype distribution of rs3775194 was statistically associated with AITDs compared with the control group. Rs3775194 was associated with AITDs under the overdominant model, both before and after adjust

SUBMITTER: Gao C 

PROVIDER: S-EPMC9296310 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature