Increased Interferon-Induced Protein With Tetracopeptides (IFITs) Reduces Mycobacterial Growth.

ABSTRACT:

Objectives

The host immune response towards Mycobacterium tuberculosis (M. tb) is known to vary with the virulence of mycobacterial species. While the majority of M. tb-exposed individuals develop latent TB infection (LTBI), a small proportion develops active TB disease. The milieu of understudied immune factors is believed to play an important role against host immune response towards mycobacteria. Here, we investigate the role of antiviral factors of the interferon-induced proteins with tetracopeptides (IFITs) family, which, in our previous research, have shown to be upregulated in response to pathogenic M. tb, but as yet have no established role in host response to bacterial infections.

Methods

We performed vector-driven overexpression a

SUBMITTER: Madhvi A 

PROVIDER: S-EPMC9296360 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature