Head-to-head Intra-individual Comparison of [⁶⁸Ga]-FAPI and [¹⁸F]-FDG PET/CT in Patients with Bladder Cancer.

ABSTRACT:

Aim/purpose

Fibroblast activation protein-(FAP)-ligands, a novel class of tracers for PET/CT imaging, demonstrated promising results in previous studies in various malignancies compared to standard [¹⁸F]FDG PET/CT. ⁶⁸Ga-labeled fibroblast activation protein inhibitor-([⁶⁸Ga]Ga-DOTA-FAPI)-PET/CT impresses with sharp contrasts in terms of high tumor uptake and low background noise leading to clear delineation. [¹⁸F]FDG PET/CT has limited accuracy in bladder cancer due to high background signal. Therefore, we sought to evaluate the diagnostic potential of [⁶⁸Ga]FAPI in patients with bladder cancer.

Material and methods

This retrospective analysis consisted of 8 patients (median age 66), 7 of whom underwent both [⁶⁸

SUBMITTER: Novruzov E 

PROVIDER: S-EPMC9296390 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature