Hip Fracture Risk After Treatment with Tramadol or Codeine: An Observational Study.

ABSTRACT:

Introduction

Hip fractures among older people are a major public health issue, which can impact quality of life and increase mortality within the year after they occur. A recent observational study found an increased risk of hip fracture in subjects who were new users of tramadol compared with codeine. These drugs have somewhat different indications. Tramadol is indicated for moderate to severe pain and can be used for an extended period; codeine is indicated for mild to moderate pain and cough suppression.

Objective

In this observational study, we compared the risk of hip fracture in new users of tramadol or codeine, using multiple databases and analytical methods.

Methods

Using data from the Clinical Practice Research Datalink and three US claims databases, we compa

SUBMITTER: Voss EA 

PROVIDER: S-EPMC9296392 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature