Investigation of urinary volatile organic compounds as novel diagnostic and surveillance biomarkers of bladder cancer.

ABSTRACT:

Background

The diagnosis and surveillance of urothelial bladder cancer (UBC) require cystoscopy. There is a need for biomarkers to reduce the frequency of cystoscopy in surveillance; urinary volatile organic compound (VOC) analysis could fulfil this role. This cross-sectional study compared the VOC profiles of patients with and without UBC, to investigate metabolomic signatures as biomarkers.

Methods

Urine samples were collected from haematuria clinic patients undergoing diagnostic cystoscopy and UBC patients undergoing surveillance. Urinary headspace sampling utilised solid-phase microextraction and VOC analysis applied gas chromatography-mass spectrometry; the output underwent metabolomic analysis.

Results

The median participant age was 70 years, 66.2% were male. Of

SUBMITTER: Lett L 

PROVIDER: S-EPMC9296481 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature