Palladium catalyzed radical relay for the oxidative cross-coupling of quinolines.

ABSTRACT: Traditional approaches for transition-metal catalyzed oxidative cross-coupling reactions rely on sp²-hybridized starting materials, such as aryl halides, and more specifically, homogeneous catalysts. We report a heterogeneous Pd-catalyzed radical relay method for the conversion of a heteroarene C(sp³)-H bond into ethers. Pd nanoparticles are supported on an ordered mesoporous composite which, when compared with microporous activated carbons, greatly increases the Pd d charge because of their strong interaction with N-doped anatase nanocrystals. Mechanistic studies provide evidence that electron-deficient Pd with Pd-O/N coordinations efficiently catalyzes the radical relay reaction to release diffusible methoxyl radicals, and highlight the difference between this surfa

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9296488 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature