Bedaquiline exposure in pregnancy and breastfeeding in women with rifampicin-resistant tuberculosis.

ABSTRACT:

Aims

We aimed to explore the effect of pregnancy on bedaquiline pharmacokinetics (PK) and describe bedaquiline exposure in the breast milk of mothers treated for rifampicin-resistant tuberculosis (TB), where there are no human data available.

Methods

We performed a longitudinal PK study in pregnant women treated for rifampicin-resistant TB to explore the effect of pregnancy on bedaquiline exposure. Pharmacokinetic sampling was performed at 4 time-points over 6 hours in the third trimester, and again at approximately 6 weeks postpartum. We obtained serial breast milk samples from breastfeeding mothers, and a single plasma sample taken from breastfed and nonbreastfed infants to assess bedaquiline exposure. We used liquid chromatography-tandem mass spectrometry to perform the b

SUBMITTER: Court R 

PROVIDER: S-EPMC9296589 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature