Effects of modafinil on electroencephalographic microstates in healthy adults.

ABSTRACT:

Rationale

Modafinil has been proposed as a potentially effective clinical treatment for neuropsychiatric disorders characterized by cognitive control deficits. However, the precise effects of modafinil, particularly on brain network functions, are not completely understood.

Objectives

To address this gap, we examined the effects of modafinil on resting-state brain activity in 30 healthy adults using microstate analysis. Electroencephalographic (EEG) microstates are discrete voltage topographies generated from resting-state network activity.

Methods

Using a placebo-controlled, within-subjects design, we examined changes to microstate parameters following placebo (0 mg), low (100 mg), and high (200 mg) modafinil doses. We also examined the functional significance of the

SUBMITTER: Linton SR 

PROVIDER: S-EPMC9296596 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature