Anti-cancer therapy is associated with long-term epigenomic changes in childhood cancer survivors.

ABSTRACT:

Background

Childhood cancer survivors (CCS) exhibit significantly increased chronic diseases and premature death. Abnormalities in DNA methylation are associated with development of chronic diseases and reduced life expectancy. We investigated the hypothesis that anti-cancer treatments are associated with long-term DNA methylation changes that could be key drivers of adverse late health effects.

Methods

Genome-wide DNA methylation was assessed using MethylationEPIC arrays in paired samples (before/after therapy) from 32 childhood cancer patients. Separately, methylation was determined in 32 samples from different adult CCS (mean 22-years post-diagnosis) and compared with cancer-free controls (n = 284).

Results

Widespread DNA methylation changes were identified post-tr

SUBMITTER: Robinson N 

PROVIDER: S-EPMC9296636 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature