Molecular mechanisms by which splice modulator GEX1A inhibits leukaemia development and progression.

ABSTRACT:

Introduction

Splice modulators have been assessed clinically in treating haematologic malignancies exhibiting splice factor mutations and acute myeloid leukaemia. However, the mechanisms by which such modulators repress leukaemia remain to be elucidated.

Objectives

The primary goal of this assessment was to assess the molecular mechanism by which the natural splice modulator GEX1A kills leukaemic cells in vitro and within in vivo mouse models.

Methods

Using human leukaemic cell lines, we assessed the overall sensitivity these cells have to GEX1A via EC₅₀ analysis. We subsequently analysed its effects using in vivo xenograft mouse models and examined whether cell sensitivities were correlated to genetic characteristics or protein expression levels. We also u

SUBMITTER: Sellin M 

PROVIDER: S-EPMC9296642 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature