Class I PI3K regulatory subunits control differentiation of dendritic cell subsets and regulate Flt3L mediated signal transduction.

ABSTRACT: Dendritic cells (DCs) play pivotal roles in initiating and shaping both innate and adaptive immune responses. The spatiotemporal expression of transcription factor networks and activation of specific signal transduction pathways determine the specification, distribution and differentiation of DC subsets. Even though pioneering studies have established indispensable roles for specific catalytic subunits (p110δ and p110γ) in immune cells, functions of the regulatory subunits, particularly of Class I PI3K, within the hematopoietic system remain incompletely understood. In the study presented here, we deleted the key regulatory subunits-p85α and p85β of the Class I_A PI3K in hematopoietic cells and studied its impact on DC differentiation. Our studies identify that a deficiency of p8

SUBMITTER: Thummar K 

PROVIDER: S-EPMC9296662 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature