Gsα^R201C and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells.

ABSTRACT: The Gsα/cAMP signaling pathway mediates the effect of a variety of hormones and factors that regulate the homeostasis of the post-natal skeleton. Hence, the dysregulated activity of Gsα due to gain-of-function mutations (R201C/R201H) results in severe architectural and functional derangements of the entire bone/bone marrow organ. While the consequences of gain-of-function mutations of Gsα have been extensively investigated in osteoblasts and in bone marrow osteoprogenitor cells at various differentiation stages, their effect in adipogenically-committed bone marrow stromal cells has remained unaddressed. We generated a mouse model with expression of Gsα^R201C driven by the Adiponectin (Adq) promoter. Adq-Gsα^R201C mice developed a complex combination of metaphyseal, diap

SUBMITTER: Palmisano B 

PROVIDER: S-EPMC9296668 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature