Early Response Assessment in Advanced Stage Melanoma Treated with Combination Ipilimumab/Nivolumab.

ABSTRACT:

Background

Standard combination ipilimumab/nivolumab (I/N) is given as 4 induction doses for advanced stage melanoma followed by nivolumab single-agent maintenance therapy. While many patients receive less than 4 doses due to immune-related toxicities, it is unclear if fewer doses of I/N may still provide long term clinical benefit. Our aim is to determine if response assessment after 1 or 2 doses of I/N can predict long-term survival and assess if fewer doses of I/N can lead to similar survival outcomes.

Methods

We performed a retrospective analysis on a cohort of patients with advanced melanoma who w0ere treated with standard I/N. Cox regression of progression-free survival (PFS) and overall survival (OS) models were performed to assess the relationship between response af

SUBMITTER: Ma VT 

PROVIDER: S-EPMC9296775 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature